💊@COVID19Up: Rarely is a drug discovered that works in so many different pathways as ivermectin. The medicine appears to work in at least three different ways to fight COVID-19 including as an anti-inflammatory, as a block for the spike protein, and as an antiviral.

The following is an excerpt from “Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action,” an article in Naunyn-Schmiedeberg’s Archives of Pharmacology, the nearly 150-year old official journal of the German Society of Experimental and Clinical Pharmacology and Toxicology.

“Ivermectin is a versatile drug with unique characteristics, which make it interesting also for basic and applied research (in particular for drug repurposing): it seems to reveal an antibacterial … antiviral, and anticancer activity ….”

Three Mechanisms of Action

1. Anti-Inflammatory Ivermectin

The key word above is “versatile.” Ivermectin works on different levels simultaneously. One surprising thing left out from the above list is “anti-inflammatory,” which is important in the fight against COVID-19, as inflammation, such as that associated with cytokine storms, is a large part of the lethality of the disease.

According to an article published by the National Academy of Sciences, “the immune response during severe COVID-19 pneumonia may progress from inhibition of viral replication to inflammatory damage that continues despite viral control.”

In other words, SARS-CoV-2 may stop multiplying in a patient but the real problem in the later stages of the disease can be the amount of inflammation in the body. If you have a drug that both inhibits the replication of the virus and reduces inflammation, it can help in multiple ways.

The article “Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19,” published in the journal Open Heart, which is the official journal of the British Cardiovascular Society, is one of many that explore the anti-inflammatory qualities of ivermectin.

“Hence, it is reasonable to suspect that, in doses at or modestly above the standard clinical dose, ivermectin may have important clinical potential for managing disorders associated with life-threatening respiratory distress and cytokine storm—such as advanced COVID-19.

Ivermectin may have been ‘flying under the radar’ in this regard during four decades of clinical use.”

2. Ivermectin Blocks the Spike Protein

Ivermectin may block the attachment of the SARS-CoV-2 spike protein to the ACE2 receptor in the human cell membrane, as explained in the article “Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2,” published by in vivo, the journal of the International Institute of Anticancer Research.

That research is also supported by this study which similarly found that ivermectin can inhibit the entry of SARS-CoV-2 to the ACE2 receptor.

3. Ivermectin Exhibits Antiviral Effects

Ivermectin is a broad-spectrum antiviral, particularly effective in vitro against RNA viruses such as Dengue virus.

Scientists are attempting to see how effective it would be against Dengue in human populations though the research is in its early stages. See the article titled “Repurposing Ivermectin as an Anti-dengue Drug” from Oxford University Press for example.

In fact, ivermectin has been shown in cell cultures to be effective against at least 19 different viruses.

In conclusion, scientists see three different mechanisms of action of ivermectin that may help a person fight off a SARS-CoV-2 infection and COVID-19. It is anti-inflammatory, it appears to block the spike protein’s connection to the ACE2 receptor, and it exhibits broad-spectrum antiviral effects.

This article is free and open source. You have permission to republish it under a Creative Commons license with attribution to COVID19Up.org.

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Comments

  1. There are more than 20 mechanisms
    Hope this helps!
    Evidence-based clinical review article- Mechanisms of action of Ivermectin against SARS-CoV-2 has been published in Springer Nature :JOA
    Click on this link to read the article
    https://www.nature.com/articles/s41429-021-00430-5

    We hope this manuscript would improve the knowledge around the so debated “I” drug.

  2. Yes, Ivermectin definitely works. Another interesting article is https://www.chinasona.org/Thiaoouba/coronavirus-en.html

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